Preparative Chromatography & Process Chromatography. Quattro Centrifugal Partition Chromatography (CPC), Quattro Counter Current Chromatography (CCC), HPLC & Flash. We can develope your Laboratory to Process CPC & CCC or Sequential CPC to Process HPLC / Flash methodology, and ensure training to impliment in your facility.

Globally Applicable Quattro CPC & CCC enable Worlwide Instrumental Liquid-Liquid, Preparative Chromatography, Plus Option Of Forcing To Completion, For Low Yield, Equilbrium Chemical Synthesis Methods. Over 30 Years International Sales. Inclusive Europe, North And South America, China, India, Singapore, Australia Etc.

Worldwide Applications of Quattro Centrifugal Partition Chromatography (CPC) & Quattro Counter Current Chromatography (CCC), Utilise Liquid-Liquid Chromatography (LLC), To Enhance Throughput & Separation Options Of Your Existing HPLC or Flash Instrumentation.

Benefits of CPC & CCCRetail PricesCustom BuildsIntroduction to use of ionic Liquids in CPC/CCCMedicinal CannabinoidsAbout UsContact Us

Dear Separation Scientist / Synthetic Chemistry /  Natural Product Chemist / Petrochemical Chemist / Environmental Chemist, etc.

Chromatography is a means to separate a single or specified mixtures of organic or inorganic compounds from complex mixtures, utilising partitioning your required compound(s) from mixtures, using differential affinity between a stationary and mobile phase, to yield the purity you require, for your research, or commerical tonnes etc. per annum purification.

Your purpose might be to achieve saleable purified product, find previously unknown bioactive compounds, test content of competitors products, or a wide vatiety of other tasks.

Solid – Liquid Chromatography (SLC) techniques, such as HPLC, SFC and Flash Chromatography, are most utilised, for analysis, and laboratory, pilot, or process scale preparations (variously picograms, to tonnes per annum).

But sometimes issues can occur with milligram to tonnes per annum, preparative or process chromatography, with “on column” absorption or degradation. Or  target compound might be too dilute to recover at a sensible cost. Or the crude mixture contains compounds that poison the SLC column, so purification cost is unacceptable for commercial use.

Liquid – Liquid Chromatography (LLC) techniques, such as CPC, CCC Chromatography utilise the same ancillary pumps, injectors, detectors, fraction collectors, control and data systems as SLC. The CPC or CCC instrument will be designed to retain one solvent, (stationary phase)  from a biphasic solvent mix, whilst the other liquid phase, not being retained, the eluent of the biphasic mixture (mobile phase), flows through, achieving the resolution you require.

With LLC you therefore use the same ancillaries as SLC, but add an electromechanical CPC or CCC chromatographic instrument, as the column, which you can utilise in addition to your non-mechanical, HPLC, SFC, Flash Chromtography column (a tube full of stationary phase), containing a solid phase, chromatographic media.

In this newly, extensively revised website, we give multiple examples, in easy to understand slideshows, of a very wide variety of research and commercial applications, of the benefits of appropriate choices for either only LLC or only SLC. If your application not shown, contact us on aecs@gmx.com for confidential discussions

But most importantly, we also show many examples where appropriate combining of LLC and SLC technologies, allows researchers to resolve problems, a single technology cannot solve, or a commercial purification, or equilibrium reaction that is not commercially viable, whilst sequential use of LLC and SLC, can provide answers to research applications, or commercial procedures..

Also shown on this Home Page are considerable details on the revised Quattro CPC and Quattro CCC, plus HPLC & Flash ranges, plus confirmation of our willingness to personally lecture any of the slideshows shown, and / or personally discuss in confidence, your own research needs for Laboratory, Pilot and Process, CPC / CCC & HPLC & Flash Chromatography.

Mass Scales:- Laboratory Scale of Milligrams, up to Industrial Scale of Tonnes Per Annum

Introducing Quattro CPC
Quattro Centrifugal Partition (CPC), Liquid-Liquid Chromatographs from 250ml to over 50 litre Capacity. Also Called Hydrostatic CCC or Sun Centrifuges

Why you need Quattro CPC or Quattro CCC. Plus Massive Benefits Of Sequential CPC-HPLC To Hugely Preconcentrate And / Or Simplify Matrix Prior to HPLC. The Latter Will Mean That Only Target Compound And A Few Similar Polarity Non-Targets, Injected into the HPLC Column, Thereby Preventing The Chance Of Poisoning Your HPLC Preparative Column: (see Slideshows for considerable extra detail).

  • Save ~50-90% process chromatography / extraction, solvent / column operating costs.
  • Ideal HPLC-MS pre-prep or sequential (CPC/CCC)-HPLC;
  • No column induced degradation or adsorption. 95+ % mass balance independently proven.
  • Uniquely allows infinitely polar to infinitely non-polar prep in one run.
  • Contract laboratory and process method development services. Contact AECS-QuikPrep.
  • Easily scale-up from milligram to grams, or to kilos, or to your tonne plus process .
  • Orthogonal selectivity options compared to HPLC / Flash / SFC.
  • No solubility problems; massive range of solvents available. Option synthesised Ionic Liquids
  • Amazing cost / resolution benefits when you combine sequentially CPC / CCC and Prep HPLC.
  • High process chromatography mass loading (typically 5 to 40 g per 1 litre capacity).
  • Inject 10 to 15% coil volume without excessive band spreading. Compare to loading Prep HPLC.
  • ENQUIRIES TO:- aecs@gmx.com. Available for Teams / Zoom lecturing CPC / CCC / Prep HPLC etc.
  • PLEASE LIST:- Mass per injection or per day or per year, and your chromatography needs.

We offer options for both Quattro CPC and Quattro CCC.

Preparative & Process Chromatography
Preparative & Process Chromatography by: Quattro CPC :- Lab to Pilot, to Tonnes Per Annum Processing, Scaleable.

INTERNATIONALLY APPLICABLE LABORATORY, PILOT AND PROCESS SCALE QUATTRO CPC & CCC, HPLC and FLASH CHROMATOGRAPHY INSTRUMENTATION.

Quattro QuikPrep™ / LabPrep™ Counter Current Chromatography units: 30, 150, 500, 1000ml to 2litre total instrument volumes. Options of up to 4 different volumes per Quattro CCC. from 30ml to 2000ml. Larger volumes can be Custom Built. Contact aecs@gmx.com for details.

Quattro QuikPrep™ / LabPrep™ Centifugal Partition Chromatography units: 100, 250, 500, 1000ml to 2litre total instrument volumes. For larger volumes see below. Contact aecs@gmx.com for details.

Quattro PilotPrep™ / ProcessPrep™ Centifugal Partition Chromatography units: 4.8litre, 12litre to 50+litre total instrument volumes. Contact aecs@gmx.com for details.

  • Quattro PilotPrep™ Centifugal Partition Chromatography
  • Quattro PilotPrep™ CPC, 4.8 Litres. Discounts for multiple orders. Purchase your own ancillaries or buy from us, or as compatible your existing Flash, HPLC Process Ancillaries, use these.
  • Quattro ProcessPrep™ Centifugal Partition Chromatography
  • Quattro ProcessPrep™ CPC, 12 Litres. Discounts for multiple orders. Purchase your own ancillaries or buy from us, or as compatible your existing Flash, HPLC Process Ancillaries, use these.
  • Quattro ProcessPrep™ CPC, 50 Litres. Discounts for multiple orders. Purchase your own ancillaries or buy from us, or as compatible your existing Flash, HPLC Process Ancillaries, use these. Larger volumes can be Custom Built.
  • Full range of HPLC / Flash Chromatography, Laboratory, Pilot / to Process Scale Ancillary Instrumentation.

Preparative & Process Chromatography by: Quattro CPC :- Lab to Pilot, to Tonnes Per Annum Processing, Scaleable
Preparative & Process Chromatography by: Quattro CPC :- Lab to Pilot, to Tonnes Per Annum Processing, Scaleable

COST, AND HOW TO SCALE UP YOUR INTERNATIONAL LABORATORY APPLICATION TO PILOT, OR TONNE PER ANNUM PLUS, PROCESS QUATTRO CENTRIFUGAL PARTITION CHROMATOGRAPHY APPLICATION?

Quattro CPC offers the potential, through their modular construction, of triple layer, three dimensionally machined, 316 Medical Grade Stainless Steel (or Custom Material) Rotor Blocks, full control of dimensions of length, and diameter, plus number of CPC chambers. You may chose from a standard range of scale up stages, with AECS known properties, or request customised rotors to suit your specific requirements. We have to date very high success in predictable scaleup from laboratory Quattro CPC to process Quattro CPC, and also from laboratory Quattro CCC to pilot scale Quattro CCC.

In certain cases, clients have transferred Quattro CCC derived methods successfully to process Quattro CPC, though we do not recommend method transfer between LLC concepts, as it offers more risk of scale up failure, than if you stay with same LLC concept.

INTRODUCTION TO USE OF, UNIQUE TO QUATTRO CPC AND CCC, HIGH PERCENTAGE IONIC LIQUID BIPHASICS IN QUATTRO CPC & CCC. QUATTRO CPC & CCC ARE REVOLUTIONISNG LIQUID-LIQUID CHROMATOGRAPHY AND EXTRACTION. JOIN US.

We believe high percentage Ionic Liquid Biphasics are the answer to major process CPC, because they are simple and easy to recycle the Biphasic Solvents, plus offer a huge variety of chemical selectivities to chose from. Ionic Liquids can be chosen to protect compound’s structure, or alternatively to cause a controlled reaction of compounds to effect, unique high yield synthesis of required products during the Quattro CPC run.

The Utilization of Ionic Liquids with Ionic Liquid-Liquid Chromatography

Click this link to read our review of Ionic Liquid-Counter Current Chromotography / Centrifugal Partition Chromotograhy {IL-CCC/IL-CPC} Research in Topics in Current Chemistry.

Quattro CCC, Standard and One-Off Designs Possible
Quattro CCC, Standard and One-Off Designs Possible

See Applications and Methodology Page Link Above For Training from International Researchers, and for Ideas on Laboratory and Process Method Development

This page gives you access to the 30+ years of AECS-QuikPrep Ltd’s experience in methodology development in CCC & CPC. Most of our research is covered by Confidentiality requirements from our clients, but some are happy for us to show non-Confidential Research. The latter also applies to the many Academic Researchers who have purchased Quattro CPC or Quattro CCC. We discuss biphasic solvent choice, preference for isocratic, exotic or step gradients, CCC and CPC methodology transfers and the potential time and cost savings of utilising Sequential CPC or CCC and Prepartive HPLC.

Plus we discuss these topics for a very wide range of chemistries, ranging from very non-polar engine oil additives etc., to mid polarity medicinal cannabinoids etc., to highly polar, only aqueous soluble sugars, polysaccharides etc.

Uniquely AECS-QuikPrep Ltd can manufacture both Hydrodynamic CCC (Planetary CCC, HSCCC, HPCCC, HPL-LC™) and Hydrostatic CCC (Droplet Centrifugal Partition Chromatography, CPC, HPCPC) at scales from 30 ml to 100+ litres. We have units in both research laboratories and process manufacture units throughout the World. We collaborate with Research Institutes / Universities, for both standard solvents and Ionic Liquid Biphasic CCC / CPC Exraction, On-Coil / On-Rotor Synthesis & Chromatography.

We can custom build for your research programme needs, to mutually agreed specification and price.

We can custom build both CCC & CPC units specific for your requirements because of our unique modular construction. Options of different CCC bore or CPC cell / chamber sizes, different volumes on the same instrument. We can custom design to accommodate your specific needs, within a mutually agreed budget. Other competitors cannot match our design and build flexibility. Just ask them and us to custom build to your specific needs and budget. We will custom build to match a mutually agreed requirement & price.

Successful Purification
Successful Purification

AECS-QuikPrep Ltd has been conducting fundamental liquid-liquid chromatography research since 1993. We have innovated many important liquid-liquid chromatography instrument designs. Others have copied, but never bettered our designs, or vaguely approach the safety features of our instrumentation.

Laboratory Quattro CPC & Quattro CCC, offer you enormous scope for researching unknown bioactivities, purifying difficult to obtain pure compounds from complex mixtures, be they natural products or synthethetic products, and host of other opportunities, which are discussed in the above Applications and Method Training Page (see second Header Button).

Quattro CPC offers the potential for massive processing cost savings, as no need to buy any solid stationary phase. Additionally, there is the cost saving of not needing to pay for disposal of contaminated used solid, stationary (silica etc) phase. With elution – extrusion, each run has new stationary phase for maximum reproducibility. Also there is potential, independently proven, to achieve 95+% injection mass recovery, and 95+% purity. The injection mass per solvent usage can also result in considerable solvent cost savings. Also as with Flash Chromatography & Process HPLC, so with CPC & CCC, with appropriate biphasic solvent choice, high cost efficiency is achieveable, through easy solvent recycling.

Contacting Us
Contacting Us, Please Give Us Your Purification Needs, and Discuss If You Might Need a Feasibility Study

The fact that AECS QuikPrep Ltd’s experience in liquid-liquid chromatography instrument design, manufacture and research, dates from 1993, compares very favourably to many of our present competitor CCC and CPC companies. Sales to China, Singapore, Indonesia, Australia, Brasil, Chile, USA, Canada, Eire, Nothern Ireland, England, France, Germany, Spain, Finland, Chechia, Switzerland. Etc.

Quattro CCC™ Planetary Motion Video (2 bobbins, 4 coils / 3 coil ids).

Note:- Door safety merchanism disabled for this demonstration video. Set spin speeds are very constant. The video judder is caused by camera/internet technology. Option of 2, 3 or 4 bores/volumes on competitor’s CCC, you would need to purchase multiple instruments. Alternatively we could custom build according to your needs, all on one Quattro CCC. Worth Thinking about?

New Options for novel Quattro CPC™, Plus a Number of New Potential Uses / Advantages

The Sun Motion Rotors can be custom made in Stainless Steel or other materials, ie Titanium etc., for proteins etc.

Quattro CPC instruments can have different chamber designs, on different rotor block sets, plus can have 2 different id cell (chamber) bore configurations, in the same Quattro CPC instrument. This gives the potential for a method development rotor and process rotor in the same Quattro CPC instrument.

Quattro CPC is ideal for MABs, proteins, peptides & enzymes, other organic and inorganic purification by chromatography.

Quattro CPC can be used to extract target compounds from complex dissolved mixtures, when using either contaminated complex crude mixtures as the mobile or the stationary phase, depending on the CPC mode chosen.

AECS’ QuikPrep Ltds unique multi-block CPC rotor design offers multiple specification options and designs, which can allow us to design for maximum resolution, or maximum throughput, or a mutually agreed compromise.

The Quattro CPC conceptual design is massively less critical, if client induced mistakes cause CPC rotor blockage. A blockage in one rotor block, can be bypassed and a slightly reduced processing rate can continue. The user can at a convenient time, remove a matched pair, and dismantle, clean and reassemble the client blocked rotor, whilst keeping production going with 2 less rotor blocks, if this is required.

Such an occurance in a stacked disc CPC design means factory repair of the whole rotor assembly, and considerable total processing downtime.

Medicinal Cannabinoid Separations.

Medicinal Cannabinoid Separations
Shown Below is a Process Ascending Chromatograph of Hemp Extract.

An Unique Offer, New to CPC Purification:- Why not consider our special combination offer, of an Quattro 250ml CPC™ for method development + Quattro 2 litre or 4.8 litre CPC™ for small scale production, with your chosen group, combined with a Quattro 12 Litre ProcessPrep CPC™, complete with appropriate ancillaries at amazing discounted prices. We are a Chromatographic Purification specialist. Which other company offers you CPC from 250ml to 12 or 50+ litre CPC™ of a modular design, at incredible prices, plus over 40 years HPLC, TLC, Flash Chromatography, plus 30 years CCC and CPC Chromatography, experience.

In addition to purchasing an instrument you will also gain from AECS-QuikPrep Ltd experience in new method development, and process chromatography. Our experience is worth your consideration. Please view the first slide show on Applications Page.

Modular design, and the use of interchangeable components are common in aerospace, car, electronics etc industries. But only AECS-QuikPrep has employed this concept to liquid-liquid chromatography. We did this to ensure the maximum likihood of successful scale-up, and ultra competitve prices.

About Us

The AECS-QuikPrep Ltd brings you scientific and design research talent, plus company stability. AECS-QuikPrep Ltd has been trading as same family-owned Company for over 40 years. Since 1983, AECS-QuikPrep Ltd has been doing contract design research for third party instrument companies. Projects included the design of moving belt HPLC-MS, HPLC-FID and HPLC-MPD detectors; evaporative light scatter detectors; the world’s first Peltier HPLC column air ovens / chillers, etc.

AECS-QuikPrep Ltd has also helped an USA based HPLC Column Company successfully productionise a completely new concept in HPLC phase product lines, which has been a commercial success for the Company, for over two decades.

AECS-QuikPrep Ltd has designed and built numerous prototype, laboratory instruments for Blue-Chip International Companies.

AECS-QuikPrep Ltd designed and built our first Quattro CCC™ in the early 1990s, when Smith Kline Beecham were not prepared to purchase the then existing CCC / CPC instrumentation, and placed an open-design Purchase Order with AECS-QuikPrep Ltd, for what became the Quattro CCC™ Mk I. They like many others, before and since, trusted AECS-QuikPrep Ltd’s conceptual design expertise, and contracted AECS-QuikPrep Ltd to build an improved design regards to both safety and performance. Since then, we have designed and built numerous custom Quattro L-LC™ for many clients. AECS-QuikPrep Ltd offers our clients proven, but ever evolving, commercially relevant CCC / CPC units. We have over 28 years of worldwide LLC commercial trading experience.

Please consider visiting our new AECS-QuikPrep Ltd’s demonstration laboratory, near Newquay Airport, only 1 hour flight from London Heathrow, and therefore with good connections to many National & International Airports.

Contact Us

Any questions, please contact us to discuss confidentially your needs by email or phone, plus we can arrange Teams, Zoom, or Google Video Link, etc., discussions / lectures based on your choice of slideshow lectures shown on the: SLIDESHOWS:- METHODOLOGY & APPLICATIONS, link on the Header Bar, above.

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Considering Laboratory or Process Chromatography
Considering Laboratory or Process Chromatography